Southampton suffered the earliest-ever relegation in Premier League history when they lost 3-1 at Tottenham Hotspur on Sunday, confirming their demotion to the second tier despite having seven games left in the season.
The visitors had needed a victory to stay alive in their fight for survival after 17th-placed Wolverhampton Wanderers moved up to 32 points with Saturday's comeback win at Ipswich Town.
But the south-coast club have only 10 points after 31 games, leaving them rock bottom and 22 points from safety.
Spurs took the lead through Brennan Johnson after Saints had a shot blocked at the other end and the Wales winger doubled their advantage just before half-time with a neatly taken goal.
Southampton struggled to threaten the Spurs goal until the 90th minute when Mateus Fernandes halved the deficit but any hopes of a comeback were extinguished when they conceded a penalty and Mathys Tel converted the spot kick to seal the three points.