Manchester United travel to Tottenham Hotspur on Sunday with what reports suggest are a host of injury problems in midfield.
In his pre-match press conference Ruben Amorim suggested that two unnamed players were a concern for him.
Amad has now confirmed that he will be out with an injury, which reports suggest is with an ankle ligament that could mean he will miss for the rest of the season.
"Extremely disappointed to be writing this message in such a crucial time of the season. Unfortunately, I will be out for some time with an injury," Amad said on his Instagram page.
Amad is United's top scorer in the league with six goals, including registering a hat-trick in a 3-1 win against Southampton.
Other reports suggest that Amorim will also not be able to call upon his midfield trio of Manuel Ugarte, Kobbie Mainoo and Toby Collyer for the trip to north London.
Man Utd are already without six other first-team players, with Lisandro Martinez also out for an extended period due to a cruciate ligament injury.
Man Utd's confirmed injury list
Player Injury Latest Update Mason Mount Muscle Details Luke Shaw Knock Details Jonny Evans Muscle Details Altay Bayindir - Details Tom Heaton - Details Lisandro Martinez Knee Details Amad Ankle Details
The Red Devils are aiming for just their fourth away win of the season but are playing a Spurs side who have beaten them twice this season, a 3-0 victory in the league and a 4-3 success in the EFL Cup.
Who could play in midfield?
If Amorim is without Collyer, Mainoo and Ugarte, the Portugese head coach may play Christian Eriksen and Casemiro at the base of his midfield. Neither has started a league match since a 2-0 defeat by Newcastle United on 30 December.
And in the five league games since then, Casemiro has been an unused substitute, while Eriksen has featured for a combined 11 minutes.