Both Manchester United and Tottenham will be eager to get their Premier League campaigns back on track, with both teams finding themselves adrift of the European spots after disappointing starts to the season.
Erik Ten Hag's side were ridiculed for their lacklustre performance against Dutch side FC Twente on Thursday, with Ten Hag criticising United's work ethic, "They [Twente] fought for every yard and we didn't."
Tottenham, meanwhile, will have increased in confidence, having won three consecutive games after their demoralising home defeat in the North London derby a fortnight ago.
At the forefront of this revitalised form is Dominic Solanke, who has now netted in consecutive matches after picking up an injury on his Spurs debut.
The last outing between the two sides in January saw the visitors come from behind twice to earn a point. Since then, Ange Postecoglou's side have picked up just two league wins on the road.
The consensus between both sets of fans is that a draw this time around would not be adequate enough, given the ambitions to secure Champions League qualification.
Despite this only being the sixth match so far this campaign, there is no doubt that defeat for either side would see intense increase in pressure from fan bases who are growing ever more impatient and frustrated with their team's lack of consistency.
Team News
Manchester United
Erik Ten Hag has no new injury concerns, but Luke Shaw, Tyrell Malacia and Leny Yoro remain sidelined for the Red Devils.
United are expected to make numerous changes after multiple fringe players failed to capitalise on their Europa League opportunity, given the underwhelming performances displayed in midweek.
Matthijs de Ligt, Kobbie Mainoo, Rasmus Hojlund and Casemiro may all be recalled to the starting lineup.
Tottenham
Postecoglou suffered an injury scare involving captain Son Heung-Min, after the South Korean was forced off in the 71st minute, with what looked like muscular cramp caused by fatigue.
Tottenham fans will be hoping that this was just a precautionary measure and that Son won't be joining the absentee list that features Richarlison and summer signing Wilson Odobert.
The visitors will also be able to recall the services of Cristian Romero, who was unavailable against Qarabag due to suspension.
Likely lineups
Manchester United
Andre Onana; Diogo Dalot, Lisandro Martinez, Matthijs de Ligt, Noussair Mazraoui; Casemiro, Kobbie Mainoo; Alejandro Garnacho, Bruno Fernandes, Amad Diallo; Rasmus Hojlund.
Tottenham
Guglielmo Vicario; Pedro Porro, Cristian Romero, Micky van de Ven, Destiny Udogie; Dejan Kulusevski, Rodrigo Bentancur, James Maddison; Son Heung-Min, Dominic Solanke, Brennen Johnson.
Key Players
Manchester United - Matthijs de Ligt
A player that made a name for himself and thrived under Ten Hag has recently been asserting his dominance in the central defensive position for his new side.
When United signed Raphael Varane in 2021 it appeared to be the signing that answered the prayers of so many fans, as United had struggled to form a resolute defensive pairing since the era of Sir Alex Ferguson.
However, Varane's three-year spell was somewhat underwhelming after failing to live up to expectation, but now the recruitment of de Ligt, who has so far played alongside Lisandro Martinez, seems to have sparked hope into a revitalised United defence.
The Dutchman has helped United keep consecutive clean sheets in their last two games and also registered his first goal, away at Southampton with a clinical, cross-goal header.
United's defence seems notably reassured with the presence and composure of de Ligt and this will be vital if they are to keep the high-pressing attack of Tottenham at bay.
Tottenham - James Maddison
The attacking midfielder, who was "devastated" to be dropped by Gareth Southgate from England's recent European Championship squad, has so far shown glimpses of the scintillating form he produced prior to picking up a long term injury in the early stages of last season.
Maddison's relentless energy has injected hope into the Spurs fans, with positive performances which have been far contrary to the lack of points so far picked up by his team.
Maddison picked up his first goal of the season in Spurs' last league outing against Brentford, with a sublime, left-footed chip to round off a fantastic performance, in which he seemed to be involved with every attack Tottenham constructed.
Match Details
Where is the game being played?
The match will take place at Old Trafford.
What time is kick off?
Kick-off is at 16:30 BST.
How can I watch?
The match will be broadcast on Sky Sports from 4pm BST.