Tottenham boss Ange Postecoglou will be without £65million striker Dominic Solanke when Everton arrive in north London today (Saturday). The former Bournemouth marksman injured his ankle against Leicester City on Monday, leaving Spurs with tricky decisions to make at the top-end of the pitch.
Son Heung-min and Richarlison are each in contention to take the centre-forward spot against a Toffees side still reeling from their hammering against Brighton in front of their own fans last weekend.
Here, Express Sport takes you through how Tottenham are likely to line up...
Tottenham's predicted XI vs Everton (4-2-3-1)
Goalkeeper: Vicario
Spurs are rumoured to be on the lookout for a new back-up goalkeeper, but that won't affect Guglielmo Vicario's immediate future as the Italian is nailed-on to continue his good work between the sticks against Everton.
Defence: Porro, Romero, Van de Ven, Udogie
Ever since Postecoglou found a winning recipe with this back-four, which is just as much about bombing forward as it is tracking back, he has stuck to his guns. Cristian Romero and Micky van de Ven are pacey and aggressive in central defence.
Radu Dragusin will be keen for more minutes this season but Spurs' starting centre-back duo will be nigh on impossible to displace if they remain injury-free. Pedro Porro and Destiny Udogie are also secure at right and left-back heading into this afternoon's fixture.
Defensive midfield: Gray, Sarr
The first of Postecoglou's difficult decisions lies in the base of his midfield. Pape Matar Sarr is a trusted player at just 21 years old, but the spot alongside him is up for grabs after the head injury Rodrigo Bentancur suffered against Leicester.
Yves Bissouma was suspended by the club for their opening match after a video emerged showing him inhaling laughing gas. The Mali international will be back in the squad at the Tottenham Hotspur Stadium, but he may have to wait patiently behind new signing Archie Gray if Postecoglou continues his strict approach.
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Attacking midfield: Johnson, Maddison, Son
James Maddison is still the string-puller in the No.10 role, but aside from that, Postecoglou could set up his front four in a number of different ways. Brennan Johnson got the nod against Leicester and should have done just enough to keep his spot on the right ahead of Dejan Kulusevski.
Out left it will either be Son or Richarlison, with the other likely to play through the middle. Son is perfectly capable of playing centrally but the South Korean is at his best when driving inside from wide areas.
Striker: Richarlison
That leaves Richarlison to lead the line in place of Solanke. It could be a huge opportunity for the Brazilian to prove his worth, with persistent rumours linking him to other clubs and the prospect of a season spent mostly on the bench at stake if Solanke finds his range.