Claudio Ranieri tries to get Roma back on track in the Europa League with Paulo Dybala, Artem Dovbyk and Mats Hummels against Tottenham, who are missing Guglielmo Vicario.
It kicks off at the Tottenham Hotspur Stadium in London at 20.00 GMT.
You can follow all the build-up and action as it happens from this game, Lazio-Ludogorets and Fiorentina-Pafos on the Liveblog.
The Giallorossi have had a disastrous 2024, firing Jose Mourinho, Daniele De Rossi and Ivan Juric, so Ranieri took over last week and made his debut in a 1-0 defeat to Napoli.
This is his third different stint at the club he has always supported and he came out of retirement to help rescue Roma’s campaign.
Dybala is back in the starting XI after his usual muscular issues, partnering Dovbyk, while Hummels gets his first start in to all intents and purposes a five-man defence.
Alexis Saelemaekers is in the squad for the first time since ankle surgery in September, but Mario Hermoso and Eldor Shomurodov didn’t make the trip.
Tottenham have quite a few problems of their own to deal with, not least the fact Italy international Vicario broke his ankle and will be out for several months, so Fraser Forster is in goal.
Cristian Romero, Richarlison, Micky van de Ven, Wilson Odobert and Mikey Moore are also out of action.
Their form has been oddly mixed, losing 3-2 to Galatasaray and 2-1 to Ipswich Town only to then crush Manchester City 4-0 at the Etihad on Saturday in the Premier League.
Ex-Juventus players Rodrigo Bentancur and Radu Dragusin start.
Italian Destiny Udogie is on the bench, but Dejan Kulusevski and Heung-min Son are in the starting XI.
Tottenham vs. Roma line-ups
Tottenham: Forster; Pedro Porro, Dragusin, B Davies, Gray; Bentancur, Sarr; Kulusevski, Johnson, Solanke; Son
Roma: Svilar; Mancini, Hummels, N’Dicka; Celik, Konè, Paredes, Angelino; El Shaarawy, Dybala; Dovbyk