Ange Postecoglou faces a decision in goal for the visit of Liverpool in the Carabao Cup semi-final first leg, with new signing Antonin Kinsky available and set to compete with Brandon Austin for a starting spot.
Austin made his long-awaited Spurs debut in Saturday's 2-1 defeat to Newcastle but Kinsky, 21, has been signed to compete to be Spurs' No1 long-term and trained with his new teammates on Monday and Tuesday. Fraser Forster, 36, returned to training on Tuesday but has been struggling with illness.
Postecoglou's back four picks itself, with Radu Dragusin recovered after being forced off at half-time through exhaustion against the Magpies.
Midfield pair Pape Matar Sarr and James Maddison are suspended on Wednesday night but Rodrigo Bentancur, who was banned at the weekend, is expected to come into the midfield, while Yves Bissouma could replace Lucas Bergvall at No6.
Spurs captain Heung-min Son, who was rested on Saturday, is likely to return to the front three, with Timo Werner set to make way.
Mikey Moore could be on the bench after returning to training following an extended period on the sidelines through illness.