The Reds can be confirmed as Premier League champions if they avoid defeat by Spurs, which would hand the club's supporters the first opportunity for an in-person title celebration in 35 years.
Speaking at his pre-match press conference on Friday morning, Slot wants his team to treat the occasion like they have done in the previous 33 league matches that got them into this position.
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He said: "First of all, that's a big responsibility because we are aware of the fact that the last time this club won the league it was COVID time.
"So, everybody is looking forward to Sunday but we know there is still a job to be done, at least one point.
"That's what we know and hopefully our fans know as well when they come to the stadium, that they support us in the best possible way they can – which is what they have done the whole season – and are aware of the fact that we still need a point.
"That's something we are definitely aware of here inside this building. So, it's a nice game to look forward to but it's also a responsibility we have for Sunday.
"First there is a game to be played against a Tottenham side that is playing for something special as well, maybe not in the league but definitely in the Europa League. So, they want to go towards Bodo/Glimt in the best possible prepared way.
"We are only focused on the next opponent and that is Tottenham now. So, we will try to prepare the team the same way we have the whole season and hopefully the team, the players, can bring the energy, the same mentality towards the game as they've brought throughout the whole season.
"And the fans, we are expecting from them the same."
With that mindset in place, any satisfaction the head coach will draw from the weekend is entirely dependent on the result.
When asked if he will be able to enjoy the game, Slot replied: "I enjoy going to Anfield every single [time] but the moment the referee blows the whistle, or even before that when I do my meetings, of course the focus is on trying to get the points or the win over the line.
"We're only settling for a win and a point is not enough. The moment you enjoy is mostly when the referee blows the whistle; these are the three, four or five minutes when you are really happy, when you walk off the pitch.
"Then you walk into a dressing room, where you always see one or two players who are not as happy as I am because they haven't played, so then already you start to think, 'OK, this has to be managed again as well.' And then I need to go to [do] the media.
"It's mostly three, four or five minutes that you are really happy and then 'normal' manager life starts again. Enjoying is what you do after the referee has blown his whistle."
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Slot is bidding to become just the fifth boss in history to win the Premier League during his first season in the competition.
Although he could not have foreseen his debut campaign playing out exactly the way it has, the Dutchman knows being in charge of Liverpool comes with the requirement of delivering success.
Slot said: "I've said many times if you come in, in the first days you are here you first of all look around you, how the training ground looks and then you start to work with your players.
"Then you are trying to get your playing style across, which we already knew we wouldn't change that much. But when players come back from holidays, when they have come back from playing for their national teams, sometimes you need to refresh them a bit and what is expected over here.
"Then, if you walk through this door, if you walk in here or at Anfield, you know the expectations, you know the expectations are this club has to win trophies – and that doesn't change when I walk through the door.
"The good thing is, as I have said a few times before, most managers work here for a long time, so you have a lot of chances to win something.
"You are aware of that but it's not the first thing you think about when you walk through this door."