Tottenham have confirmed defender Radu Dargusin will undergo surgery on an anterior cruciate ligament (ACL) injury - adding to Spurs' defensive injury woes.
The Romanian defender picked up the blow during Spurs' Europa League victory over Elfsborg last week and raises serious concerns over whether the centre-back will feature again this season.
Dragusin's lengthy spell on the sidelines adds to the absence of Cristian Romero and Destiny Udogie in the defensive areas for Spurs, who only welcomed back Micky van de Ven from injury last week.
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Spurs did alleviate their defensive injury woes with the £21m signing of Lens defender Kevin Danso from Lens, havig seen a late £70m bid for Crystal Palace captain Marc Guehi rejected.
But it leaves the Austrian, the returning Van de Ven and utiity player Archie Gray as their only recognised centre-back options.
And Spurs are entering an important part of their season with a Carabao Cup semi-final second leg with Liverpool on Thursday night, plus an FA Cup fourth round tie away at Aston Vila on Sunday.
Ange Postecoglou's side, who sit 14th in the Premier League table, also have league games against Man City, Bournemouth and Chelsea within the next two months.
Tottenham's next 10 games
February 6: Liverpool (a), Carabao Cup semi-final second leg - live on Sky Sports
February 9: Aston Villa (a), FA Cup fourth round
February 16: Man Utd (h) - live on Sky Sports
February 22: Ipswich (a)
February 26: Man City (h)
March 9: Bournemouth (h) - live on Sky Sports
March 16: Fulham (a)
April 2: Chelsea (a)
April 5: Southampton (h)
April 12: Wolves (a)
Tottenham's transfer window analysed
Sky Sports News' Michael Bridge:
"Mathys Tel was arguably the most high-profile signing on Deadline Day.
"Tel told Spurs on Friday he wanted to stay at Bayern Munich but after a weekend of thinking and a long conversation with Ange Postecoglou, the deal was back on as we revealed at midday on Monday afternoon.
"Spurs also successfully negotiated a £45m option to buy in the deal.
"Kevin Danso arrived from Lens on Saturday night, while goalkeeper Antonin Kinsky has enjoyed an impressive start after his transfer from Slavia Prague.
"Spurs had been working to bring in another defender after Danso, due to a serious knee injury to Radu Dragusin.
"They had a significant bid rejected for Crystal Palace defender Marc Guehi over the weekend, with reports suggesting it was worth up to £70m.
"Supporters will hope Danso and Tel hit the ground running with a crucial week ahead in the Carabao Cup and FA Cup."