The Change for Tottenham protest group are planning "to visibly signal dissatisfaction" with events in north London at the next home game against Crystal Palace by not taking their seats for the beginning of the second half.
The move is the latest escalation of an ongoing protest movement by a growing fringe supporters group that aims to put pressure on Daniel Levy and the wider Enic ownership group, featuring the Lewis family trust.
They say that the club needs to stop putting "profit before glory" and supporters will repeat their protests from recent matches against Liverpool, Manchester United and Southampton by gathering before kick-off and marching to the stadium. Fans are also encouraged to wear yellow.
There were already noticeably empty seats in some sections of the stadium on Monday as Spurs lost 2-1 at home to Nottingham Forest.
This comes amid the backdrop of a season which could be the club's worst in the Premier League era. After 33 games, Spurs are 16th on 37 points having lost 18 matches.
They need to pick up eight more points to surpass their worst total in a single Premier League campaign, which came in the 1997-98 season, under a combination of Gerry Francis and Christian Gross as permanent managers.
They also need to avoid a further two defeats to avoid breaking the record 19 defeats suffered that season.
At the moment, Spurs are five matches without a win at Tottenham Hotspur Stadium in the league and have already suffered more defeats (eight) on home turf than they had in any other 38-game season.
Because of these struggles, manager Ange Postecoglou is understood to be under some pressure when he faces a post-season review, regardless of whether Tottenham win the Europa League.