Dominic Solanke will miss Tottenham's clash with Everton on Saturday through injury.
The £65million signing picked up a knock in Monday’s 1-1 draw at Leicester City and has failed to recover in time for the visit of Sean Dyche's side.
Spurs boss Ange Postecoglou reassured fans the injury was not serious but stopped short of guaranteeing his return for next weekend's trip to Newcastle.
"Dom picked up a knock in the last game. He got through the game but it flared up the day after and he'll miss the game tomorrow," Postecoglou said.
"It's an ankle injury, he copped it really early on, someone went across his ankle.
"It just depends on his recovery [when he returns], obviously we've got the international break, but it's not serious."
Postecoglou confirmed that Richarlison is fit to start against the Toffees after his brief cameo at the King Power Stadium.
The Brazilian had been linked with a move away from the club ahead of next week's transfer deadline, but Solanke’s injury could see him stay put, for now.
Goalscorer against the Foxes, Pedro Porro, is available after limping off with a foot complaint while Rodrigo Bentancur will miss out due to concussion protocol.
Postecoglou addressed the situation surrounding Yves Bissouma who was suspended by the club after posting a video of himself inhaling nitrous oxide on social media.
The Malian missed Spurs’ Premier League opener, however Postecoglou revealed the player is available but there is still work to be done.
“Biss is available but we've got some options there,” the Spurs boss added. “The whole idea of trying to bulk up the squad is for these situations.
“He's available for selection. The bridge building continues.”
Postecoglou’s side controlled the first half against Leiecster but allowed the Foxes to gain an upper hand and pick up a point.
Spurs will hope they can take inspiration from last season’s form where they opened with a draw at Brentford before going on a nine-game unbeaten run which saw them take top spot into the Autumn.
The fixtures are coming thick and fast for Tottenham with trips to Newcastle and Manchester United and the north London derby against Arsenal to come before the end of September.
Postecoglou will hope to have Solanke fit and ready for the onslaught of high-profile fixtures as well as the return of the Europa League.