Pedro Porro, who was given a rare rest for the 1-0 defeat at Chelsea, continues at right-back, while Ben Davies deputises for Micky van de Ven at centre-half.
Yves Bissouma has been replaced at half-time in three of his last five starts, so Lucas Bergvall, who only played an hour against the Blues, continues at No6.
Postecoglou remains without Dejan Kulusevski (foot), Kevin Danso (hamstring) and Radu Dragusin (knee) but said he had no fresh injury concerns after a 16th defeat of the league season at Stamford Bridge on Thursday.
Asked if he would rotate at Saints, who Spurs beat 5-0 at St. Mary's in December, Postecoglou said: "To a certain extent, we are a little bit beyond that as the group is in a decent place physically where I don’t have to get players gametime.
"As I said, it is about getting some momentum leading into the game on Thursday. We will make a couple of changes but we won’t make too many."