Mikel Arteta has no choice but to be bold with his team selection as a decimated Arsenal face Tottenham in the north London derby.
The Gunners enter the first derby of the season this weekend in better form, but it is Spurs who head into the clash in finer spirits.
The Lilywhites are set to welcome back some key players as they look to get one over their biggest rivals after a slow start to the season.
Meanwhile, the Gunners are going to be without two of their stars and it’s an absence that will force Arteta to experiment with his side.
There's likely to be a debut for one Deadline Day signing, with several other players deployed out of position to cover the hole in midfield.
Here, talkSPORT.com takes a look at the injury latest and predicts how both teams could line up this weekend…
Tottenham
Spurs are coming into this huge derby off the back of their first defeat of the new Premier League campaign against Newcastle.
Ange Postecoglou’s side have now won, drawn and lost so far this season, with performances not reaching the level needed to compete at the top just yet.
However, Tottenham will be boosted by the return of two players who missed the last game.
The first of those players is Micky van de Ven, who sat out of the trip to Newcastle after seemingly picking up a knock against Everton.
Postecoglou confirmed that he ‘wasn’t quite 100 per cent’ and that due to the busy schedule after the international break, he was rested - missing the Netherlands' Nations League games as a result.
So it is likely that Van de Ven will be back fit to feature alongside Cristian Romero at centre-back, with Pedro Porro and Destiny Udogie on either side.
Guglielmo Vicario will be in goal behind them, of course.
In midfield, Yves Bissouma will sit deeper than Pape Matar Sarr and James Maddison, with the latter looking to create for a very dangerous front three.
And in that trio should see the second returnee in Dominic Solanke, who after missing two straight games, has rested over the break and is likely to be involved against Arsenal.
He’ll be flanked by captain Heung-min Son and potentially Dejan Kulusevski, who seems to be preferred to Brennan Johnson.
Summer signing Wilson Odobert may not be ready just yet to play in such a huge game.
Arsenal
The visitors are yet to lose this season but they’re now having to deal with some issues.
Before the international break, Declan Rice was controversially sent off against Brighton and that meant he was suspended for this game.
Jurrien Timber also seemed to pick up a knock during that Seagulls draw, hobbling off the Emirates pitch as he was substituted.
However, during the break, Timber has featured for the Netherlands and looks fit to play alongside William Saliba and Gabriel in defence this weekend.
That is fortunate for the Gunners, considering their other preferred option at left-back, Riccardo Calafiori was sent home early by Italy after sustaining an injury.
There is no doubt that Ben White will keep his place at right-back having enjoyed a rest due to his ongoing England exile.
That is the only slither of good fortune Arsenal have enjoyed during the international fixtures, with Martin Odegaard set to be sidelined.
The club captain limped out of Norway's 2-1 win over Austria with an ankle pain that his coach Ola Solbakken admitted looked bad.
The 25-year-old is a permanent starting fixture on the right side of Arteta's midfield three in his favoured 4-3-3 formation when fit.
Arsenal are yet to confirm Odegaard's absence officially, but the early prognosis is that he will miss around three weeks and leave his manager with a choice of whether to stick or twist now that the spine of his team has been decimated.
Kai Havertz could slot back into a No.8 position over youngster Ethan Nwaneri where he started his Gunners career rather than as a striker.
That would allow Arteta to maintain his 4-3-3 shape by pushing Thomas Partey into a more advanced area, with Jorginho as the No.6.
Havertz's absence from attack means Arsenal would be sweating on the return of Gabriel Jesus, with Leandro Trossard also offering an option as a false nine following his absence from the Belgium squad.
With so many players out of form or adjusting to new positions, Arteta may lean on the experience of Raheem Sterling over the struggling Gabriel Martinelli in such a big game.
Arsenal's new no. 30 last played a competitive game in May having missed out on Euro 2024 before being exiled by Chelsea.
But having joined the Gunners on a season-long loan deal during deadline day, Sterling has been hard at work at London Colney.
The winger is already familiar with Arteta's methods following their work together at Manchester City and wouldn't be fazed by making his debut in such a big game.
If Sterling isn't fit enough to start, Jesus may be the one taken a gamble on with a dramatic shift to a bold 4-2-4 formation.
Bukayo Saka is the undisputed choice at right-wing in both lineups, but Havertz's recent form may mean he's too valuable in attack.
Jorginho and Partey would become a double-pivot midfield to shield the defence, with Trossard playing in a more familiar role on the left.
Havertz would then be tasked with playing in a two-man striker setup that he operates in for Germany alongside the returning Jesus.
This would simultaneously ease the pressure on Sterling to come in from the start and instead be an impact option off the bench.